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  The Insuperable Statistics of Naturalistic Polypeptide Synthesis - In Other Words, Nature Cannot Design Complex Proteins Titin is the largest protein in the human body. It consists of 38,138 amino acid residues in a precise sequence.  The first, original synthesis, whether stepwise or in one single, continuous process, consisted of "selecting," in any manner you contemplate, 1 out of the 20 amino acids making up humans, one at a time, 38,138 times in succession.  The probability of this event is 1/20 38,138   , which equals  1 in 1 0 49,618 , times the other factors.     The pretense of claiming that "sections" of any protein were "assembled" overlooks the unassailable fact that any "section," however small, had to be assembled under the same statistical constraints.  Whether one does the computations in one step or 100,000 steps, the figures are beyond dispute.  They get a great deal worse, in fact.   Only Levorotary (left-handed) amino acids,